1,4-Diacetylbenzene

1,4-Diacetylbenzene (1,4-DAB) is a tetradentate ligand that binds to metal ions. It has been used to model the active site of acetylcholinesterase, as well as for supramolecular chemistry. 1,4-DAB has been shown to have anticholinesterase activity and is used in crosslinkers. 1,4-DAB forms hydrogen bonds with the nitrogen atom of the carbonyl group and also stabilizes molecules through its dipole interactions. The kinetic properties of 1,4-DAB have been studied by modelling studies and by Nuclear Magnetic Resonance spectroscopy. Metformin hydrochloride (MET) is a biguanide antihyperglycemic agent that inhibits glucose production in the liver and promotes insulin sensitivity in peripheral tissues.